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. 2015 Mar 31;3(1):e35. doi: 10.15190/d.2015.27

Figure 2. Schematic drawings of NF-κB/Rel proteins. Structures of the mammalian NF-κB, IκB, and IKK proteins.

Figure 2

The number of amino acids in each protein is indicated on the right. Presumed sites of cleavage for p105/NF-κB1 (amino acid 433) and p100/NF-κB2 (amino acid 447) are shown on the top of each protein. The positions of functional domains are indicated, including the Rel homology domain (RHD), DNA binding domain (DBD), dimerization domain (DM), nuclear localization signal (NLS), transactivation domains (TD). TA1 and TA2 subdomain of TD presented in RelA and cRel, glycine-rich hinge region (GGG), ankyrin repeats (ANK), double serine phosphorylation sites (SS), leucine zipper (LZ), helix-loop-helix (HLH), NEMO-binding domain (NBD), α-helix (H), coiled coil (CC), and zinc finger (Z).