TABLE 1.

Sizes of the large-scale 16S rRNA data sets included in this study^a

Data set	No. of samples									Sequencing platform	Sequencing region
	G-1	G-2	G-3	G-4	G-5	G-6	G-7	G-8	Total
Zeller	50	38	41				48	48	225	Illumina_MiSeq	V4
Flemer	62	23	69	59	31	2	74	65	385	Illumina_MiSeq	V3_V4
Burns							44	44	88	Illumina_MiSeq	V5_V6
Baxter	172	198	120						490	Illumina_MiSeq	V4
China_GBA				61	52	52	52	52	269	P_454	V1_V4
MAL2							21	23	44	Illumina_MiSeq	V3_V4
MAL1				6			20	21	47	Illumina_MiSeq	V3_V4
Zackular	30	30	30						90	Illumina_MiSeq	V4
Kostic							60	55	115	P_454	V3_V5
PNAS				11	2	2	23	23	61	P_454	V3_V5
Brazil				18				18	36	ION_TORRENT	V4_V5
China_KM							8	8	16	P_454	V1_V2
China_SH				20	31	31			82	Illumina_MiSeq	V3_V4
China_QD	11		10						21	Illumina_HiSeq_2500	V3_V4
China_SHTJ							65	65	130	Illumina_MiSeq	V4
Total	325	289	270	175	116	87	415	422	2,099	NA	NA

^aG-1, Normal_Stools (healthy control stool samples); G-2, CRA_Stools (colorectal adenoma stool samples); G-3, CRC_Stools (colorectal carcinoma stool samples); G-4, Normal_Tissue (healthy control colorectal tissue); G-5, CRA_Tissue_Adjacent (colorectal adenoma adjacent tissue); G-6, CRA_Tissue (colorectal adenoma tissue); G-7, CRC_Tissue_Adjacent (colorectal carcinoma adjacent tissue); G-8, CRC_Tissue (colorectal carcinoma tissue); NA, not available.