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. 2020 Apr 15;6(16):eaay6515. doi: 10.1126/sciadv.aay6515

Fig. 5. Overexpression of a dominant-negative mutant of N-WASP (NLS-CA) interferes with the temporal dynamics of Pol II clusters.

Fig. 5

Burst size, burst lifetime, and the number of bursts per cluster in cells overexpressing NLS-CA under serum stimulation (n = 115 bursts of 50 clusters from 10 cells) and normal growth (n = 152 bursts of 67 clusters from 13 cells) conditions, cells under serum stimulation condition (n = 323 bursts of 55 clusters from 11 cells), and cells under normal growth condition (n = 149 bursts of 65 clusters from 13 cells). Data are shown as means ± SEM. Statistical significance was determined by one-way ANOVA with Tukey-Kramer test. **P < 0.01 and ***P < 0.001.