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. 2020 Apr 15;6(16):eaaz7602. doi: 10.1126/sciadv.aaz7602

Fig. 2. Meiotic errors in early embryos.

Fig. 2

(A) Example of a two-cell embryo (E29) analyzed with Strand-seq containing a loss of chromosome 22 due to a meiotic error in the maternal germline. The remaining chromosome 22 is enriched for paternal SNVs. The embryo also contains a reciprocal mitotic copy number change on chromosome 20. (B) Karyogram of six sequenced cells from one embryo showing meiotic losses of chromosomes 13 and 14. Only the paternally inherited copies of chromosome 13 and 14 are present, indicating that the meiotic errors occurred on the maternal alleles.