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. Author manuscript; available in PMC: 2021 Mar 5.
Published in final edited form as: Cell Stem Cell. 2020 Mar 5;26(3):309–329. doi: 10.1016/j.stem.2020.02.011

Figure 2: Evolution of multi-lineage hiPSC-derived platforms and comparison of model throughput versus physiological relevance.

Figure 2:

Since the discovery of hiPSCs in 2007, hiPSC-derived multi-lineage platforms have grown in complexity from simple, two-dimensional cultures to engineered platforms and complex organoids. These hiPSC-derived multi-lineage platforms strive to maintain a balance between high throughput and high physiological relevance, with an ideal model exhibiting both characteristics. Future work may incorporate hiPSCs in humanized animal models and organ chimeras to enable human tissue production in large animals.