. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2019 Nov 20;29(1):10–21. doi: 10.1158/1055-9965.EPI-18-1123

Table 3:

Costs and effects (discounted at 5%) per 1,000 simulated 40-year-olds of all uniform screening scenarios assuming a) perfect adherence and b) realistic adherence

a. Effects of uniform screening scenarios assuming perfect adherence

Screening Strategy			FITs	Colonoscopies	Complications	CRC Incidence	CRC Mortality	Life Years^a	Total QALYs^a	Total Costs^ab	ICER^ab
Test	Start Age	Interval	FITs	Colonoscopies	Complications	CRC Incidence	CRC Mortality	Life Years^a	Total QALYs^a	Total Costs^ab	ICER^ab
No Screening			0	84	0.07	84	29	17,872	17,847	1,234,089
FIT	60	3	3,981	467	0.24	66	19	17,889	17,867	1,240,498	317
FIT	60	2	5,935	576	0.27	62	16	17,892	17,871	1,256,805	4,314
FIT	54	3	5,571	561	0.28	64	18	17,894	17,873	1,304,332	Dominated
FIT	60	1	9,954	777	0.34	56	15	17,895	17,875	1,327,965	Dominated
FIT	54	2	8,101	695	0.32	59	16	17,898	17,878	1,343,651	11,768
FIT	50	3	6,990	625	0.30	63	17	17,897	17,877	1,371,842	Dominated
FIT	50	2	9,473	759	0.34	59	15	17,901	17,881	1,436,505	Dominated
FIT	46	3	7,789	660	0.29	63	17	17,898	17,878	1,462,077	Dominated
FIT	54	1	13,381	953	0.40	53	14	17,902	17,884	1,480,562	23,324
FIT	46	2	10,767	811	0.35	59	16	17,902	17,883	1,556,681	Dominated
FIT	50	1	15,397	1,042	0.43	53	14	17,905	17,887	1,634,262	43,174
FIT	40	3	9,187	707	0.30	64	18	17,899	17,879	1,635,282	Dominated
FIT	40	2	12,532	868	0.36	60	16	17,903	17,884	1,789,931	Dominated
COL	60	10	0	2,198	0.60	42	11	17,900	17,881	1,789,986	Dominated
FIT	46	1	17,171	1,109	0.44	54	14	17,906	17,889	1,830,442	122,612
COL	60	5	0	3,048	0.82	37	10	17,902	17,883	2,117,448	Dominated
FIT	40	1	19,338	1,165	0.44	57	16	17,906	17,888	2,201,540	Dominated
COL	54	10	0	2,928	0.86	39	10	17,907	17,889	2,294,199	Dominated
COL	50	10	0	3,245	0.91	37	9	17,911	17,893	2,706,770	Dominated
COL	54	5	0	4,540	1.16	31	7	17,911	17,894	3,016,912	Dominated
COL	46	10	0	3,341	1.01	39	10	17,912	17,895	3,181,465	Dominated
COL	50	5	0	5,012	1.24	29	7	17,916	17,899	3,664,480	184,883
COL	40	10	0	4,269	1.09	36	9	17,916	17,898	4,319,443	Dominated
COL	46	5	0	5,700	1.35	30	7	17,919	17,902	4,593,188	349,139
COL	40	5	0	7,011	1.57	26	6	17,924	17,904	6,462,019	648,900
b. Effects of uniform screening scenarios assuming realistic adherence

Screening Strategy			FITs	Colonoscopies	Complications	CRC Incidence	CRC Mortality	Life Years^a	Total QALYs^a	Total Costs^ab	ICER^ab
Test	Start Age	Interval	FITs	Colonoscopies	Complications	CRC Incidence	CRC Mortality	Life Years^a	Total QALYs^a	Total Costs^ab	ICER^ab

No Screening			0	84	0.07	84	29	17,872	17,847	1,234,089	Dominated
FIT	60	3	1,952	228	0.14	77	24	17,879	17,855	1,249,846	1,936
FIT	60	2	3,022	285	0.16	74	23	17,881	17,857	1,259,357	3,446
FIT	54	3	2,488	255	0.15	76	24	17,880	17,857	1,278,301	Dominated
FIT	60	1	5,427	398	0.21	69	20	17,885	17,863	1,292,600	6,544
FIT	54	2	3,931	328	0.18	73	22	17,884	17,860	1,300,838	Dominated
FIT	50	3	3,253	288	0.17	75	23	17,882	17,859	1,310,216	Dominated
FIT	50	2	4,721	361	0.19	72	22	17,885	17,863	1,346,432	Dominated
FIT	46	3	3,691	305	0.16	75	23	17,883	17,860	1,351,925	Dominated
FIT	54	1	7,355	478	0.24	67	19	17,890	17,868	1,373,779	15,702
FIT	46	2	5,504	390	0.20	72	22	17,887	17,864	1,407,164	Dominated
FIT	40	3	4,500	332	0.17	75	23	17,884	17,861	1,435,530	Dominated
FIT	50	1	8,779	529	0.26	66	19	17,892	17,871	1,459,998	29,326
COL	60	10	0	987	0.30	65	21	17,884	17,862	1,460,994	Dominated
FIT	40	2	6,651	425	0.21	72	22	17,888	17,866	1,528,067	Dominated
COL	54	10	0	1,048	0.35	67	21	17,884	17,862	1,550,987	Dominated
FIT	46	1	10,156	573	0.27	66	19	17,894	17,873	1,572,125	56,064
COL	60	5	0	1,413	0.45	60	18	17,887	17,865	1,592,938	Dominated
COL	50	10	0	1,176	0.37	65	21	17,886	17,864	1,679,843	Dominated
FIT	40	1	12,108	626	0.28	67	19	17,895	17,874	1,792,630	151,031
COL	54	5	0	1,825	0.55	57	17	17,890	17,869	1,821,556	Dominated
COL	46	10	0	1,215	0.43	66	21	17,887	17,865	1,831,735	Dominated
COL	50	5	0	2,040	0.60	55	17	17,893	17,873	2,050,622	Dominated
COL	40	10	0	1,622	0.47	62	19	17,890	17,868	2,218,841	Dominated
COL	46	5	0	2,377	0.67	53	16	17,896	17,876	2,395,405	Dominated
COL	40	5	0	2,986	0.79	50	15	17,901	17,880	3,102,085	221,941

Abbreviations: COL = colonoscopy; CRC = colorectal cancer, FIT = faecal immunological test; ICER = incremental cost-effectiveness ratio; QALYs = quality-adjusted life years

Grey shading highlights uniform screening scenarios on the efficient frontier prior to considering personalised screening.

^a.

Results are discounted at an annual rate of 5%

^b.

Costs are presented in Australian Dollars ($AUD)