Table 1:

List of original publication describing analyzing exosomes as biomarkers in MS

	Publication	Journal	Source of exosomes	Cargo analyzed
1	Azimi et al., 201941	Iran J Allergy Asthma Immunol	T cell cultures	miRNA
2	Saenz-Cuesta et al., 201842	Viruses	plasma	miRNA
3	Pieragostino et al., 201843	Sci Rep	CSF	lipids
4	Olascoaga et al., 201842	Int J Mol Sci	T cell cultures	functional assays
5	Martelli et al., 201844	Viruses	urine	miRNA
6	Manna et al., 201840	Faseb J	serum	miRNA
7	Mallardi et al., 201845	Sci Rep	serum	equivalent vesicle radius, number of EV, lipids, total RNA concentration
8	Kimura et al., 201846	Nat Commun	plasma	miRNA
9	Galazka et al., 201836	MS J	serum, CSF	proteins
10	Soundara Rajan et al., 201747	Int J Immunopathol Pharmacol	human periodontal ligament stem cells cultures	functional assays
11	Selmaj et al., 201727	Ann Neurol	serum	total transcriptome, miRNA
12	Ebrahimkhani et al., 201748	Sci Rep	serum	miRNA
13	Singh et al., 201649	J Neuroimmune Pharmacol	urine	miRNA
14	Moyano et al., 201650	J Neurosci Res	plasma	lipids
15	Lee et al., 201639	Clin Chim Acta	CSF	proteonomic profile
16	Giovannelli et al., 201551	J Neurovirol	plasma, urine	miRNA