Table 2 –

Risk gene discovery in OCD

Gene	# de novo LGD	# de novo Mis-D	# transmitted LGD	# non-transmitted LGD	# transmitted Mis-D	# non-transmitted Mis-D	p-value	q-value (FDR)
SCUBE1	1	1	0	0	0	0	2.96 × 10−6	0.091
CHD8	1	1	0	0	0	0	3.57 × 10−6	0.098
TTN	0	3	1	1	9	10	0.0006	0.63

We used the TADA algorithm (He et al., 2013) to estimate the likelihood of observing gene-level recurrence of de novo damaging variants in three genes in unrelated individuals. Two of these genes, SCUBE1 and CHD8, exceeded the false discovery rate (FDR) threshold for high-confidence risk genes (q<0.1). Despite observing three de novo damaging variants in TTN, this gene did not meet criteria for a high-confidence or even a probable (q<0.3) risk gene, owing to its large size and high expected de novo mutation rate. See also Figure S5, Tables S2–S3, Table S5.