Fig. 1.

C.elegans kinome (A) and phosphatome (B). Percentage of reviewed kinase/phosphatase entries that are active or inactive. The distribution of pseudokinases/pseudophosphatases according to the type of evidence supporting the lack of catalytic activity is shown. Figures reproduced from [41]. (C) Clustal Omega alignment [46] of the catalytic site sequence of C.elegans myotubularins. The consensus sequence for the catalytic motif (C-X₅-R; C:Cysteine, X: any amino acid, R:arginine) is highlighted and the cysteine intermediate is highlighted in orange in the active myotubularin-related (MTMR) proteins.