Fig. 5.

Example of the annotation of a protein with two catalytic domains, one active and one inactive. PPIL2 (UniProtKB Q13356) has an active ubiquitin ligase domain while its peptidyl-prolyl cis-trans isomerase domain is not functional. For the ubiquitin ligase domain (U-box), whose positions are indicated in the “Family & Domains” section, the name, the EC number and catalytic activity provide information related to its active status. For the peptidyl-prolyl cis-trans isomerase domain (PPIase cyclophilin-type), whose positions are indicated in the “Family & Domains” section, its inactive status is reflected in the name (“Inactive..”) and in the caution comment where the evidence for the lack of activity is provided.