Fig. 6.

UniProtKB curation process for enzymes. Potential enzyme entries are selected, an expert curator assesses the evidence available (identification/curation step). Based on the evidence, an annotation specific for enzyme or pseudoenzyme is made (annotation step). The entries are integrated into the reviewed/Swiss-Prot section of the UniProtKB database. Template entries corresponding to well characterized enzymes are selected to create rules for automatic annotation which are then applied to the unreviewed entries. These entries can be retrieved using the UniProtKB search engine.