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. 2020 Apr 15;37(4):83. doi: 10.1007/s11095-020-2777-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — (a) Average daily release of TAF equivalent from 0.8 cm, 16.8 mg TAF (▲), and 1.6 cm 33.9 mg TAF (∆) implants used in animal PK and safety studies. Implants were made with Tecoflex™ EG-85A RCM (2.2 mm OD, 150 μm thickness) with a core pellet composition of 96:2:2 wt% TAF:NaCl:MgSt. Error bars represent standard deviation (n = 10, n = 9 for 1.6 cm implant). (b) Average daily release of TAF parent (■) and TAF related species; PMPA monoamidate (*), monophenyl PMPA (∆) and TFV (●) from the same 0.8 cm implant above. Error bars represent standard deviation (n = 10). Numeric values given in Table S-III. (c) Cumulative % release of TAF equivalent from 0.8 cm (▲) and 1.6 cm (□) implants. Error bars represent standard deviation (n = 10, n = 9 for 1.6 cm implant). (d) TAF parent (1) is tenofovir alafenamide without the fumarate salt, which undergoes pH-dependent hydrolysis into two main related substances monophenyl PMPA (2) and PMPA monoamidate (3). These are the Generation A implants of the recent Su et al. (27).