Table 2.
GO term enrichment reveals prominent T- and B-lymphocyte activation in immune-infiltrated tumor samples.
| GO term | Description | Gene ratio | Background ratio | p-Value | p-adjust |
|---|---|---|---|---|---|
| GO:0030098 | Lymphocyte differentiation | 36/376 | 344/18493 | 7.01E − 16 | 2.63E − 12 |
| GO:0070661 | Leukocyte proliferation | 31/376 | 283/18493 | 2.26E − 14 | 4.25E − 11 |
| GO:0002429 | Immune response-activating cell surface receptor signaling pathway | 37/376 | 414/18493 | 4.14E − 14 | 5.18E − 11 |
| GO:0002768 | Immune response-regulating cell surface receptor signaling pathway | 38/376 | 445/18493 | 7.79E − 14 | 6.85E − 11 |
| GO:0050851 | Antigen receptor-mediated signaling pathway | 29/376 | 259/18493 | 9.12E − 14 | 6.85E − 11 |
| GO:0042113 | B-cell activation | 31/376 | 303/18493 | 1.46E − 13 | 9.14E − 11 |
| GO:0050854 | Regulation of antigen receptor-mediated signaling pathway | 15/376 | 57/18493 | 3.23E − 13 | 1.73E − 10 |
| GO:0046651 | Lymphocyte proliferation | 28/376 | 264/18493 | 9.51E − 13 | 4.47E − 10 |
| GO:0032943 | Mononuclear cell proliferation | 28/376 | 266/18493 | 1.14E − 12 | 4.78E − 10 |
| GO:0042100 | B-cell proliferation | 17/376 | 91/18493 | 3.53E − 12 | 1.33E − 09 |
| GO:0042110 | T-cell activation | 35/376 | 451/18493 | 1.22E − 11 | 4.16E − 09 |
| GO:0045785 | Positive regulation of cell adhesion | 32/376 | 397/18493 | 3.63E − 11 | 1.14E − 08 |
| GO:1903039 | Positive regulation of leukocyte cell–cell adhesion | 23/376 | 214/18493 | 8.22E − 11 | 2.38E − 08 |
| GO:0007159 | Leukocyte cell − cell adhesion | 28/376 | 327/18493 | 1.59E − 10 | 4.13E − 08 |
| GO:0050870 | Positive regulation of T-cell activation | 22/376 | 202/18493 | 1.65E − 10 | 4.13E − 08 |
| GO:0050852 | T-cell receptor signaling pathway | 19/376 | 150/18493 | 2.23E − 10 | 5.24E − 08 |
| GO:0050867 | Positive regulation of cell activation | 30/376 | 384/18493 | 3.25E − 10 | 7.18E − 08 |
| GO:0022409 | Positive regulation of cell – cell adhesion | 24/376 | 251/18493 | 3.62E − 10 | 7.57E − 08 |
| GO:0050855 | Regulation of B-cell receptor signaling pathway | 9/376 | 24/18493 | 5.39E − 10 | 1.07E − 07 |
| GO:0030183 | B-cell differentiation | 17/376 | 125/18493 | 6.55E − 10 | 1.22E − 07 |
Top 20 most-enriched GO-BP terms within differentially expressed genes between samples displaying high vs. low levels of leukocytic infiltrate.