Table 3.
Correlations between ASV biomarkers and clinical variables.
| ASV increased in HT group | Clinical variable | Spearman correlation index | p.value Spearman correlation | p.adjust Spearman correlation |
|---|---|---|---|---|
| s718. Ruminococcaceae, Pygmaiobacter | SBP | 0.4586 | 0.0003 | 0.0399 |
| s718. Ruminococcaceae, Pygmaiobacter | DBP | 0.3565 | 0.0056a | 0.1238 |
| s394. Lachnospiraceae | FBG | 0.4208 | 0.0009 | 0.0492 |
| s394. Lachnospiraceae | SBP | 0.3966 | 0.0019 | 0.0755 |
| s394. Lachnospiraceae | DBP | 0.3242 | 0.0122 | 0.1542 |
| s394. Lachnospiraceae | Fat mass | 0.3561 | 0.0076 | 0.1283 |
| s1498. Ruminococcaceae | FBG | 0.2894 | 0.0262b | 0.2304 |
| ASV increased in NT group | Clinical variable | Spearman correlation index | p.value Spearman correlation | p.adjust Spearman correlation |
| s230. Bacteroides xylanisolvens | cLDL | −0.3318 | 0.0103 | 0.1416 |
| s451. Lachnospiraceae | TG | −0.3346 | 0.0096 | 0.1359 |
| s372. Faecalibacterium prausnitzii | DBP | −0.4334 | 0.0006 | 0.0417 |
| s372. Faecalibacterium prausnitzii | SBP | −0.4031 | 0.0015 | 0.0750 |
| s524. Christensenellaceae_R-7_group | DBP | −0.3054 | 0.0186c | 0.1871 |
| s524. Christensenellaceae_R-7_group | SBP | −0.3075 | 0.0178d | 0.1830 |
| S458. Ruminococcaceae_UCG-014 | DBP | −0.3402 | 0.0083e | 0.1283 |
p is probability at α = 0.05.
SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, tryglicerides; cLDL low density liproprotein cholesterol; FBG, fasting blood glucose. Variables were adjusted for age, waist circumference, cLDL, BMI, fat mass and total fiber intake.
aConfounding factor: Fat mass (p value = 0.058).
bConfounding factor: Fat mass (p value = 0.0614).
cConfounding factors: Age (p value = 0.0514), waist circumference (p value = 0.1676); total fiber intake (p value = 0.0578).
dConfounding factors: Waist circumference (p value = 0.092); total fiber intake (p value = 0.054).
eConfounding factor: Fat mass (p value = 0.067).