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. 2020 Apr 15;11:1845. doi: 10.1038/s41467-020-15598-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Preincubation of XPO5 enhances the microprocessor cleavage of pri-mir-19a. Incubation of increasing amount of XPO5 leads to increased processing efficiency of pri-mir-19a (lanes 3–6). Incubation of increasing amount of the XPO5 mutant also results in increased processing efficiency of pri-mir-19a (lanes 8–11). b Preincubation of XPO5 and XPO5 mutant enhances the microprocessor cleavage of truncated pri-mir-19a v1. c Preincubation of increasing amounts of XPO5 does not promote the cleavage efficiency of pri-mir-19a truncation v2 by the microprocessor. Representative images of three independent repeats are shown for each assay (a–c). (Quan. = quantification). Original data for all panels are provided in the Source Data file. .