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. 2020 Apr 15;10:6478. doi: 10.1038/s41598-020-63634-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro activity of CIK against chemo-surviving pdOVC. (A) CIK are capable of killing residual pdOVC that survived therapeutic doses (IC₅₀, 72 hours) of carboplatin in vitro. CIK cytotoxicity is fully comparable, with a trend to superiority, with paired control against untreated pdOVC. (B) Tumor killing was evaluated by flow cytometry. The figure shows representative flow-cytometry dot plots reporting the decrease of viable tumor cells during treatment with CIK.