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. 2020 Apr 15;10:6457. doi: 10.1038/s41598-020-63540-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Slow4 DMN hemodynamic variability was associated with baseline global cognition, hippocampal volume and cognitive decline. After ICA-based denoising, lower variability in the posterior DMN was associated with poorer baseline global cognition (A) and smaller hippocampal volume (B) at slow4. Furthermore, over a 2-year follow-up, lower posterior DMN variability was associated with faster cognitive decline at slow4 in all patients (C). GSR approach showed similar correlation patterns as described in the text. ANG = angular gyrus; GSR = Global signal regression; ICA = Independent component PCUN = Precuneus. *Correlations surviving multiple comparisons correction. (2-column fitting image).