Table 4.

The concentrations of inflammatory cytokines were detected by a protein chip array in rats administered different doses of RFRP-3 or vehicle treated for 14 d.

Parameters	Control (0 μg/100 μL)	RFRP-3 (1 μg/100 μL)	RFRP-3 (10 μg/100 μL)
IL-1α (pg/ml)	44.49 ± 2.04	61.03 ± 2.57**	51.98 ± 2.87
IL-1β (pg/ml)	49.62 ± 2.24	126.91 ± 7.23***	65.56 ± 3.69##
IL-2 (pg/ml)	128.55 ± 2.89	129.50 ± 3.00	122.15 ± 3.34
IL-4 (pg/ml)	3.66 ± 0.23	3.51 ± 0.18	3.59 ± 0.21
IL-6 (pg/ml)	45.69 ± 2.14	49.02 ± 1.91	52.69 ± 2.42
IL-10 (pg/ml)	176.41 ± 2.91	168.45 ± 3.90	172.42 ± 0.93
IL-13 (pg/ml)	63.43 ± 1.04	62.72 ± 1.15	62.44 ± 1.23
MCP-1 (pg/ml)	362.36 ± 28.68	494.09 ± 31.36**	415.37 ± 26.85
IFN-γ (pg/ml)	11.60 ± 0.54	11.76 ± 0.31	11.58 ± 0.32
TNF-α (pg/ml)	65.63 ± 1.31	116.69 ± 3.95***	74.92 ± 2.78#

Data are mean ± SEM; n = 10 rats/group.

^**p < 0.01 and

^***p < 0.001 RFRP-3 1 μg/100 μL vs. vehicle;

^#p < 0.05 and

^##p < 0.01 RFRP-3 10 μg/100 μL vs. vehicle.