Table 4.
Table of factors potentially associated with mortality
| Factor | Category | Subjects | Events | Difference | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total, n | Overall split, % | Split by birth era, % | Total, n | Overall split, % | Split by birth era, % | ||||||
| Pre-2000 | Post-2000 | Pre-2000 | Post-2000 | Hazard ratio (95% CI) | Significance, P | ||||||
| Sex | Males | 1087 | 60.35 | 59.58 | 60.42 | 41 | 68.30 | 56.25 | 76.00 | 1.49 (0.77-2.91) | .241 |
| Females | 39.65 | 40.42 | 39.58 | 31.70 | 43.75 | 24.00 | 1 | ||||
| TTI status | Yes | 1087 | 1.66 | 5.32 | 1.31 | 41 | 9.76 | 12.50 | 8.00 | 3.4 (1.12-10.34) | .031 |
| No | 98.34 | 94.68 | 98.69 | 90.24 | 87.50 | 92.00 | 1 | ||||
| Splenectomy | Done | 1064 | 10.24 | 36.95 | 7.71 | 41 | 14.63 | 12.50 | 8.00 | 1 | .23 |
| Not done | 89.76 | 63.05 | 92.29 | 85.37 | 87.50 | 92.00 | 1.77 (0.7-4.46) | ||||
| HBV vaccination status | Done | 1087 | 84.36 | 85.11 | 84.29 | 41 | 68.29 | 62.50 | 72.00 | 1 | .000305 |
| Not done | 15.64 | 14.89 | 15.71 | 31.71 | 37.50 | 28.00 | 3.45 (1.75-6.81) | ||||
| Economic status | APL | 1056 | 17.33 | 42.39 | 14.94 | 36 | 25.00 | 26.67 | 23.81 | 1 | .88 |
| Below poverty line | 82.67 | 57.61 | 85.06 | 75.00 | 73.33 | 76.19 | 1.06 (0.47-2.39) | ||||
| Distance from treatment center | <150 km | 1042 | 6.62 | 7.53 | 6.53 | 41 | 17.07 | 12.50 | 20.00 | 1.36 (0.57-3.24) | .49 |
| >150 km | 93.38 | 92.47 | 93.47 | 82.93 | 87.50 | 80.00 | 1 | ||||
| Cardiac status | Normal | 501 | 94.81 | 83.95 | 96.90 | 21 | 80.95 | 70.00 | 90.91 | 1 | .1 |
| Complication | 5.19 | 16.05 | 3.10 | 19.05 | 30.00 | 9.09 | 2.8 (0.88-8.89) | ||||
| Ferritin level | Moderate (≤2000) | 1062 | 36.91 | 16.48 | 38.83 | 35 | 14.29 | 0.00 | 23.81 | 0.9412 (.30-2.93) | .92 |
| High (2000-4000) | 41.90 | 36.26 | 42.43 | 22.86 | 7.14 | 33.33 | 1 | ||||
| Severe (>4000) | 21.19 | 47.25 | 18.74 | 62.86 | 92.86 | 42.86 | 4.66 (1.93-11.29) | .00063 | |||
| Rate of drop of Hb | Moderate (≤1) | 1060 | 43.68 | 50.00 | 43.09 | 38 | 50.00 | 46.67 | 52.17 | 1.99 (0.95-4.13) | .0667 |
| High (1-2) | 52.08 | 45.56 | 52.68 | 31.58 | 33.33 | 30.43 | 1 | ||||
| Severe (>2) | 4.25 | 4.44 | 4.23 | 18.42 | 20.00 | 17.39 | 7.71 (2.92-20.4) | .000038 | |||
| Age of start of transfusion | Age ≤2 y | 1034 | 74.56 | 59.77 | 75.92 | 32 | 68.75 | 36.36 | 85.71 | 1 | .95 |
| Age >2 y | 25.44 | 40.23 | 24.08 | 31.25 | 63.64 | 14.29 | 1.03 (0.46-2.28) | ||||
| Length of follow-up at center | FUP <2 y | 1087 | 42.32 | 36.17 | 42.90 | 41 | 73.17 | 87.50 | 64.00 | 1 | |
| FUP 2-4 y | 34.04 | 30.85 | 34.34 | 19.51 | 6.25 | 28.00 | 0.135 (0.061-0.30) | 8.67 × 10−7 | |||
| FUP >4 y | 23.64 | 32.98 | 22.76 | 7.32 | 6.25 | 8.00 | 0.03 (0.009-0.097) | 7.7 × 10−9 | |||
APL, above poverty line; FUP, follow-up.