Table 4.
End points | Donor KIR haplotype, AA vs Bx | Donor KIR Cen regions score, AA vs AB vs BB | Donor KIR Tel regions score, AA vs AB vs BB | Donor KIR B content score, neutral vs better vs best | Donor KIR B content score, 1 vs 2 vs 3 vs 4 | Alternative donor KIR B content score, 0-1 vs 2 ≤ | KIR B composite score, 4 vs 3 vs 2 | KIR2DS1 score, no vs yes |
---|---|---|---|---|---|---|---|---|
Survival | P = .78 | P = .38 | P = .54 | P = .42 | P = .89 | P = .67 | P = .28 | P = .33 |
AA, n = 240 | AA, n = 354 | AA, n = 424 | Neutral, n = 491 | 0, n = 240 | 0-1, n = 491 | 2, n = 184 | No, n = 438 | |
Bx, n = 473 | AB, n = 292 | AB, n = 246 | Better, n = 155 | 1, n = 251 | 2+, n = 222 | 3, n = 415 | Yes, n = 275 | |
BB, n = 67 | BB, n = 43 | Best, n = 67 | 2, n = 169 | 4, n = 114 | ||||
3+, n = 53 | ||||||||
DFS | P = .67 | P = .36 | P = .16 | P = .28 | P = .96 | P = .98 | P = .22 | P = .71 |
AA, n = 238 | AA, n = 350 | AA, n = 421 | Neutral, n = 488 | 0, n = 238 | 0-1, n = 488 | 2, n = 183 | No, n = 432 | |
Bx, n = 468 | AB, n = 289 | AB, n = 244 | Better, n = 151 | 1, n = 250 | 2+, n = 218 | 3, n = 411 | Yes, n = 274 | |
BB, n = 67 | BB, n = 41 | Best, n = 67 | 2, n = 165 | 4, n = 112 | ||||
3+, n = 53 | ||||||||
TRM | P = .46 | P = .09 | P = .35 | P = .08 | P = .61 | P = .61 | P = .19 | P = .55 |
AA, n = 238 | AA, n = 350 | AA, n = 421 | Neutral, n = 488 | 0, n = 238 | 0-1, n = 488 | 2, n = 183 | No, n = 432 | |
Bx, n = 468 | AB, n = 289 | AB, n = 244 | Better, n = 151 | 1, n = 250 | 2+, n = 218 | 3, n = 411 | Yes, n = 274 | |
BB, n = 67 | BB, n = 41 | Best, n = 67 | 2, n = 165 | 4, n = 112 | ||||
3+, n = 53 | ||||||||
Relapse | P = .46 | P = .82 | P = .13 | P = .76 | P = .86 | P = .46 | P = .71 | P = .73 |
AA, n = 238 | AA, n = 350 | AA, n = 421 | Neutral, n = 488 | 0, n = 238 | 0-1, n = 488 | 2, n = 183 | No, n = 432 | |
Bx, n = 468 | AB, n = 289 | AB, n = 244 | Better, n = 151 | 1, n = 250 | 2+, n = 218 | 3, n = 411 | Yes, n = 274 | |
BB, n = 67 | BB, n = 41 | Best, n = 67 | 2, n = 165 | 4, n = 112 | ||||
3+, n = 53 | ||||||||
aGVHD II-IV | P = .79 | P = .54 | P = .73 | P = .33 | P = .21 | P = .46 | P = .90 | P = .09 |
AA, n = 191 | AA, n = 271 | AA, n = 326 | Neutral, n = 369 | 0, n = 191 | 0-1, n = 369 | 2, n = 135 | No, n = 329 | |
Bx, n = 344 | AB, n = 212 | AB, n = 182 | Better, n = 114 | 1, n = 178 | 2+, n = 166 | 3, n = 320 | Yes, n = 206 | |
BB, n = 52 | BB, n = 27 | Best, n = 52 | 2, n = 129 | 4, n = 80 | ||||
3+, n = 37 | ||||||||
aGVHD III-IV | P = .02 | P = .02 | P = .57 | P = .04 | P = .04 | P = .11 | P = .67 | P = .42 |
AA, n = 212 | AA, n = 311 | AA, n = 372 | Neutral, n = 427 | 0, n = 212 | 0-1, n = 427 | 2, n = 160 | No, n = 372 | |
Bx, n = 409 | AB, n = 251 | AB, n = 215 | Better, n = 135 | 1, n = 215 | 2+, n = 194 | 3, n = 362 | Yes, n = 242 | |
BB, n = 59 | BB, n = 34 | Best, n = 59 | 2, n = 151 | 4, n = 99 | ||||
3+, n = 43 | ||||||||
cGVHD | P = .45 | P = .17 | P = .36 | P = .18 | P = .22 | P = .36 | P = .51 | P = .93 |
AA, n = 237 | AA, n = 350 | AA, n = 419 | Neutral, n = 485 | 0, n = 237 | 0-1, n = 485 | 2, n = 182 | No, n = 432 | |
Bx, n = 467 | AB, n = 288 | AB, n = 242 | Better, n = 153 | 1, n = 248 | 2+, n = 219 | 3, n = 409 | Yes, n = 272 | |
BB, n = 66 | BB, n = 43 | Best, n = 66 | 2, n = 167 | 4, n = 113 | ||||
3+, n = 52 | ||||||||
Neutrophil engraftment | P = .76 | P = .56 | P = .28 | P = .68 | P = .51 | P = .71 | P = .44 | P = .38 |
AA, n = 242 | AA, n = 356 | AA, n = 426 | Neutral, n = 493 | 0, n = 242 | 0-1, n = 493 | 2, n = 184 | No, n = 439 | |
Bx, n = 474 | AB, n = 293 | AB, n = 247 | Better, n = 156 | 1, n = 251 | 2+, n = 223 | 3, n = 418 | Yes, n = 277 | |
BB, n = 67 | BB, n = 43 | Best, n = 67 | 2, n = 170 | 4, n = 114 | ||||
3+, n = 53 | ||||||||
Platelet engraftment | P = .09 | P = .57 | P = .28 | P = .48 | P = .36 | P = .23 | P = .51 | P = .42 |
AA, n = 240 | AA, n = 354 | AA, n = 423 | Neutral, n = 490 | 0, n = 240 | 0-1, n = 490 | 2, n = 183 | No, n = 437 | |
Bx, n = 472 | AB, n = 291 | AB, n = 246 | Better, n = 155 | 1, n = 250 | 2+, n = 222 | 3, n = 415 | Yes, n = 275 | |
BB, n = 67 | BB, n = 43 | Best, n = 67 | 2, n = 169 | 4, n = 114 | ||||
3+, n = 53 |