Table 6.
Test accuracy for diagnostic strategy
| Test result | No. of results per 1000 patients tested (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | |
|---|---|---|---|---|
| Prevalence 15%*† in patients suspected of having LE DVT | Prevalence 40%*† in patients suspected of having LE DVT | |||
| True positives | 146 (132-149) | 388 (352-396) | 105 (1) | ⊕⊕◯◯Low‡ |
| False negatives | 4 (1-18) | 12 (4-48) | ||
| True negatives | 842 (731-850) | 594 (516-600) | 105 (1) | ⊕⊕◯◯Low‡ |
| False positives | 8 (1-119) | 6 (1-84) | ||
| Inconclusive test results | 0 | 105 (1) | ||
| Complications arising from the diagnostic test | NA | |||
An interactive version of this table is available at: https://gdt.gradepro.org/presentations/#/isof/isof_4adf9db8-ffbe-4f56-a2f8-49d45ed834db-1582834742820?_k=b92mdh.
D-dimer for “DVT unlikely” patients (if positive proximal compression US; if negative 3-month follow-up); proximal compression US for “DVT likely” patients (if positive repeat US at 1 week, if negative rule out). Patient or population: Patients with suspected recurrent lower extremity deep vein thrombosis. Setting: Inpatient and outpatient. Pooled sensitivity: 0.97 (95% CI, 0.88-0.99). Pooled specificity: 0.99 (95% CI, 0.86-1.00).
Prevalence of recurrent VTE was estimated to be 13% (1 year) to 30% (10 years) based on the review (20% used in the table).61
Clinical PTP and D-dimer used to evaluate patients with suspected recurrent DVT, prevalence 44.8% (40% used in table).56
Certainty of evidence was downgraded twice for serious imprecision given the small population size from the 2 recurrent lower extremity DVT studies identified for analysis.