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. 2020 Mar 30;4(7):1250–1264. doi: 10.1182/bloodadvances.2019000960

Table 8.

Test accuracy for serial ultrasound in patients with suspected recurrent lower extremity DVT

Test result No. of results per 1000 patients tested (95% CI) No. of participants (studies) Certainty of the evidence (GRADE)
Prevalence 15%* in patients suspected of having LE DVT Prevalence 40%* in patients suspected of having LE DVT
True positives 144 (129-149) 384 (344-396) 205 (1) ⊕⊕◯◯ Low
False negatives 6 (1-21) 16 (4-56)
True negatives 850 (808-850) 600 (570-600) 205 (1) ⊕⊕◯◯ Low
False positives 0(0-42) 0 (0-30)
Inconclusive test results 0 205 (1)
Complications arising from the diagnostic test NA

Patient or population: Patients with suspected recurrent lower extremity deep vein thrombosis. Setting: Inpatient and outpatient. Pooled sensitivity: 0.96 (95% CI, 0.86-0.99). Pooled specificity: 1.00 (95% CI, 0.95-1.00).

*

Prevalence of recurrent VTE was estimated to be 13% (1 year) to 30% (10 years) based on the review (20% used in the table).61

Clinical PTP and D-dimer used to evaluate patients with suspected recurrent DVT, prevalence 44.8% (40% used in table).56

Certainty of evidence was downgraded twice for serious imprecision given the small population size from the 2 recurrent lower extremity DVT studies identified for analysis.