FIGURE 2.
Casp-1/11 deficiency impairs in vivo antigen-specific CD8+ T cell expansion in response to LM-OVA. (A,B) Frequency and (C) total number of OVA257–264 (SIINFEKL)-specific CD8+ T cells in the spleens of infected mice at 7 days after LM-OVA vaccination, revealed by staining with anti-CD8 antibody and H2-Kb-SIINFEKL dextramer. Results are expressed as (A) selected representative image per group or (B,C) representative bar graphic of three independent experiments showing the mean and standard error of five mice per group. Statistical analysis was performed by using two-way ANOVA followed by Bonferroni post-tests. *p < 0.5, ***p < 0.001.