Table 7.
Univariate Cox regression
| Variable | All-cause mortality |
Liver-related mortality |
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Etiology | ||||
| NASH-HCC | 1.00 | 1.00 | ||
| ASH-HCC | 1.31 (0.94–1.68) | 0.09 | 1.48 (1.31–2.14) | 0.03 |
| Age | 1.01 (0.99–1.04) | 0.39 | 1.01 (0.98–1.03) | 0.58 |
| Gender | ||||
| Female | 1.00 | 1.00 | ||
| Male | 1.40 (0.83–2.36) | 0.21 | 1.44 (0.81–2.54) | 0.21 |
| DM | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.14 (0.74–1.74) | 0.56 | 1.07 (0.67–1.70) | 0.77 |
| HTN | ||||
| No | 1.00 | 1.00 | ||
| Yes | 1.21 (0.76–1.91) | 0.43 | 1.08 (0.66–1.76) | 0.76 |
| HLD | ||||
| No | 1.00 | 1.00 | ||
| Yes | 0.86 (0.56–1.33) | 0.49 | 0.77 (0.48–1.24) | 0.28 |
| Cirrhosis | ||||
| No | 1.00 | 1.00 | ||
| Yes | 0.77 (0.49–1.22) | 0.27 | 0.67 (0.39–1.38) | 0.37 |
| Albumin | 0.93 (0.90–0.96) | <0.001 | 0.94 (0.91–0.98) | 0.001 |
| ALP | 1.005 (1.003–1.007) | <0.001 | 1.005 (1.003–1.007) | <0.001 |
| ALT | 1.001 (0.99–1.01) | 0.90 | 1.004 (0.99–1.02) | 0.50 |
| AST | 1.007 (1.004–1.009) | <0.001 | 1.007 (1.005–1.009) | <0.001 |
| GGT | 1.001 (1.00009–1.002) | 0.04 | 1.001 (1.0002–1.003) | 0.02 |
| AFP | 1.000003 (1.000001–1.000006) | 0.01 | 1.000004 (1.000001–1.000006) | 0.004 |
| Total bilirubin | 1.005 (1.002–1.009) | 0.004 | 1.006 (1.002–1.009) | 0.001 |
| Serum creatinine | 1.003 (1.0001–1.005) | 0.04 | 1.002 (0.999–1.005) | 0.23 |
| MELD Score | 1.05 (1.004–1.09) | 0.03 | 1.05 (1.007–1.10) | 0.02 |
| CTP Score | 1.29 (1.16–1.44) | <0.001 | 1.26 (1.12–1.42) | <0.001 |
| Portal vein involved | ||||
| No | 1.00 | 1.00 | ||
| Yes | 3.35 (2.08–5.40) | <0.001 | 3.79 (2.27–6.35) | <0.001 |
| Lymph node involved | ||||
| No | 1.00 | 1.00 | ||
| Yes | 4.35 (2.29–8.25) | <0.001 | 3.86 (1.90–7.84) | <0.001 |
| TNM staging (AJCC 7th ed) | ||||
| I | 1.00 | 1.00 | ||
| II | 1.88 (1.004–3.52) | 0.05 | 1.82 (0.91–3.66) | 0.09 |
| III | 3.00 (1.75–5.14) | <0.001 | 2.94 (1.64–5.28) | <0.001 |
| IV | 8.58 (4.08–18.03) | <0.001 | 9.50 (4.30–20.97) | <0.001 |
HR, hazard ratio; CI, confidence interval; NASH, non-alcoholic steatohepatitis; HCC, hepatocellular carcinoma; ASH, alcoholic steatohepatitis; DM, diabetes mellitus; HTN, hypertension; HLD, hyperlipidaemia; ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase; GGT, gamma glutamyl transferases; AFP, alpha-fetoprotein; MELD, model for end-stage liver disease; CTP, Child-Turcotte-Pugh; TNM, Tumor lymph Node Metastasis; AJCC, American Joint Committee on Cancer.