Figure 3.

In vivo antitumor activity of 5c and amonafide in HCC tumors. Eight mice each received the vehicle, amonafide (5 mg/kg), 5c (3 mg/kg), or 5c (5 mg/kg). (A) Relative weight of the mice for PBS, amonafide, and 5c group. (B) Tumor weight for PBS, amonafide, and 5c group at the end of the experiment. (C) Images of the tumors for PBS, amonafide, and 5c group at the end of the experiment. First horizontal line, control group; second line, amonafide group (5 mg/kg); third line, 5c group (3 mg/kg); fourth line, 5c group (5 mg/kg). (D) Organ weight indexes [(organ weight/body weight) × 100%] including heart, liver, kidney, lung, and spleen were calculated for PBS, amonafide, and 5c group at the end of the experiment. ***P < 0.001.