Table 3.
Co‐occurrence of androgen receptor gene amplifications and mutations in circulating tumor DNA
| Alteration | n | Percent of total patients | Percent of patients with co‐mutation |
|---|---|---|---|
| Amplification only | 165 | 18.67 | |
| Isolated mutation | 368 | 41.63 | |
| Co‐mutation | 351 | 39.71 | |
| AMP + L702H | 83 | 9.39 | 23.65 |
| L702H + H875Y | 32 | 3.62 | 9.12 |
| AMP + L702H + T878A | 21 | 2.38 | 5.98 |
| AMP + W742C | 21 | 2.38 | 5.98 |
| L702H + T878A + H875Y | 17 | 1.92 | 4.84 |
| AMP + T878A | 15 | 1.70 | 4.27 |
| T878S + H875Y | 14 | 1.58 | 3.99 |
| AMP + W742C + W742L | 13 | 1.47 | 3.70 |
| T878S + W742C | 13 | 1.47 | 3.70 |
| AMP + H875Y | 11 | 1.24 | 3.13 |
| W742C + W742L | 9 | 1.02 | 2.56 |
| L702H + T878A | 8 | 0.90 | 2.28 |
| AMP + L702H + H875Y | 7 | 0.79 | 1.99 |
Abbreviation: AMP, amplification.