Table 2.
Top five most frequent single‐agent and combination chemotherapy of COT across all LOTs and by individual LOTs
| All COT LOTs | 1L | 2L | 3L and greater | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Single regimen | % | Combo regimen | % | Single regimen | % | Combo regimen | % | Single regimen | % | Combo regimen | % | Single regimen | % | Combo regimen | % |
| All patients | |||||||||||||||
| cape | 23.7 | AC | 31.2 | cape | 27.9 | AC | 37.2 | cape | 20.8 | carbo+gem | 27.8 | cape | 19.9 | carbo+gem | 25.0 |
| eribulin | 12.6 | carbo+gem | 18.9 | nab pac | 12.4 | carbo+gem | 16.1 | pac | 18.6 | AC | 21.7 | eribulin | 17.6 | AC | 9.4 |
| nab pac | 12.5 | TC | 11.0 | carbo | 10.4 | TC | 14.3 | eribulin | 13.6 | cyclo+fluor+MTX | 5.3 | nab pac | 12.7 | cyclo+fluor+MTX | 7.0 |
| gem | 9.9 | carbo+pac | 5.9 | gem | 10.1 | carbo+pac | 7.3 | nab pac | 12.5 | carbo+docet | 4.6 | gem | 11.6 | carbo+docet | 3.9 |
| pac | 9.7 | cyclo+fluor+MTX | 4.3 | pac | 9.5 | cyclo+fluor+MTX | 3.6 | gem | 7.9 | carbo+pac | 4.2 | lipo doxo | 11.5 | carbo+nab pac | 3.5 |
| TNmBC | |||||||||||||||
| cape | 20.0 | AC | 21.5 | cape | 28.1 | carbo+gem | 26.8 | cape | 21.1 | carbo+gem | 36.5 | eribulin | 20.9 | carbo+gem | 33.3 |
| eribulin | 13.2 | carbo+gem | 27.4 | nab pac | 11.5 | AC | 24.4 | eribulin | 17.2 | AC | 17.1 | cape | 12.5 | cyclo+fluor+MTX | 10.7 |
| nab pac | 10.8 | TC | 6.8 | carbo | 11.4 | carbo+pac | 9.8 | nab pac | 14.1 | carbo+docet | 4.4 | gem | 11.8 | AC | 9.3 |
| gem | 9.7 | carbo+pac | 7.9 | gem | 10.7 | TC | 8.5 | pac | 9.8 | cyclo+fluor+MTX | 4.4 | nab pac | 10.8 | carbo+docet | 5.3 |
| pac | 6.5 | cyclo+fluor+MTX | 4.0 | eribulin | 10.6 | carbo+docet | 3.7 | gem | 9.1 | carbo+pac | 3.9 | vin | 10.4 | carbo+nab pac | 2.7 |
| HR+/HER2− | |||||||||||||||
| cape | 26.2 | AC | 40.2 | cape | 26.1 | AC | 51.6 | pac | 44.9 | AC | 32.3 | cape | 19.7 | carbo+gem | 26.2 |
| eribulin | 11.5 | TC | 17.8 | pac | 20.2 | TC | 23.6 | cape | 16.1 | carbo+gem | 11.3 | eribulin | 17.0 | cyclo+fluor+MTX | 8.2 |
| nab pac | 14.7 | carbo+gem | 9.0 | nab pac | 15.2 | TC + doxo | 4.4 | nab pac | 8.7 | carbo+pac | 6.5 | lipo doxo | 13.7 | AC | 6.6 |
| gem | 9.8 | cyclo+fluor+MTX | 5.6 | gem | 7.5 | cyclo+fluor+MTX | 4.4 | docet | 5.9 | carbo + nab pac | 6.5 | nab pac | 13.1 | carbo+nab pac | 5.7 |
| pac | 17.1 | carbo+pac | 3.3 | docet | 7.1 | carbo+pac | 3.5 | lipo doxo | 4.7 | cyclo+fluor+MTX | 6.5 | gem | 11.4 | carbo+docet | 5.0 |
| HR+/HER2− | |||||||||||||||
| cape | 44.0 | AC | 59.6 | cape | 40.7 | AC | 73.8 | cape | 45.0 | Cyclo+epiru+fluor | 50.0 | cape | 32.9 | carbo+gem | 12.8 |
| eribulin | 11.4 | carbo+gem | 5.6 | gem | 14.8 | TC | 9.5 | pac | 20.0 | carbo+nab pac | 12.5 | nab pac | 18.5 | AC | 12.8 |
| nab pac | 20.2 | TC | 9.0 | nab pac | 14.8 | carbo+pac | 4.8 | nab pac | 10.0 | TC + doxo | 12.5 | eribulin | 13.7 | carbo+docet | <1 |
| gem | 14.0 | carbo+pac | 3.4 | docet | 11.1 | cape + ixabepilone | 2.4 | carbo | 5.0 | AC | 12.5 | gem | 13.7 | gem+nab pac | <1 |
| pac | 5.2 | carbo+docet | 3.4 | pac | 7.4 | carbo+docet | 2.4 | docet | 5.0 | gem+vin | 12.5 | lipo doxo | 8.2 | nab pac | <1 |
| HR−/HER2+ | |||||||||||||||
| cape | 41.8 | AC | 45.2 | cape | 30.3 | AC | 53.7 | cape | 39.1 | AC | 41.7 | cape | 29.8 | AC | 20.0 |
| eribulin | 14.6 | carbo+gem | 13.7 | pac | 18.2 | carbo+pac | 12.2 | lipo doxo | 13.0 | carbo+docet | 25.0 | eribulin | 14.9 | carbo+gem | 10.0 |
| nab pac | 11.7 | TC | 5.5 | nab pac | 15.2 | carbo+gem | 9.8 | docet | 8.7 | cyclo+fluor+MTX | 25.0 | lipo doxo | 10.6 | cape+nab pac | 10.0 |
| gem | 6.8 | carbo+pac | 6.8 | carbo | 12.1 | TC | 9.8 | pac | 8.7 | cape+eribulin | 12.5 | gem | 6.4 | cisplatin+gem | 5.0 |
| pac | 8.7 | cyclo+fluor+MTX | 2.7 | lipo doxo | 6.1 | Cyclo+epiru | 4.9 | nab pac | 8.7 | cisplatin+gem | 0.6 | vin | 6.4 | carbo+lipo doxo | <1 |
Abbreviations: AC, doxorubicin and cyclophosphamide; carbo, carboplatin; COT, chemotherapy‐only treatment; gem, gemcitabine; cape, capecitabine; cyclo, cyclophosphamide; cis, cisplatin; docet, docetaxel; doxo, doxorubicin; erib; eribulin; fluor, fluorouracil; HR, hormone receptor; lipo, liposomal; LOT, line or therapy; MTX, methotrexate; nab pac, nab paclixatel; pac, paclitaxel; TC, docetaxel and cyclophosphamide.