Table 7.
Summary of positive (↑) and negative (↓) effect of HF medication on adverse outcomes (mortality and HF hospitalization) in the HFmrEF
| Study | MRA | ACE‐i | ARB | Beta‐blocker | Diuretics | Statin |
|---|---|---|---|---|---|---|
| Pitt et al. TOPCAT63 | ↑ | |||||
| Xiang et al.64 | ↑ | |||||
| Fonarow et al. OPTIMIZE‐HF65 | = | = | ||||
| Tsuji et al.18 | = | = | ↑ | ↓ | = | |
| Yusuf et al. CHARM‐PRESERVED66 | ↑ | |||||
| Koh et al.10 | ↑ | ↑ | ↑ | ↑ | ||
| Lund et al. CHARM programme8 | ↑ |
ACE‐i, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; MRA, mineralocorticoid receptor antagonist.