Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 23;7(2):493–502. doi: 10.1002/ehf2.12593

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Immunocytochemical detection of 5‐mC in cardiomyocytes in endomyocardial biopsy specimens at the electron microscopic level. Immunogold particles bound to 5‐mC localize predominantly in heterochromatin in both normal (A) and bizarrely shaped (B) nuclei. The bizarrely shaped nucleus is rich in heterochromatin where immunogold particles are abundant. Panels A′ and B′ are highly magnified and lightly printed images of the boxed areas in panels A and B, respectively. They highlight the relationship between heterochromatin and immunogold particles. Scale bars, 1 μm. (C) Graph showing comparison of the number of 5‐mC bound immunogold particles between controls (n = 6) and DCM patients (n = 6). (D) Graph showing fraction of the 5‐mC bound immunogold particles localized on heterochromatin in controls (n = 6) and DCM patients (n = 6).