Table 2.
Invasive haemodynamic measurements
| Parameters | WT‐Sham (n = 6) | KO‐Sham (n = 6) | WT‐Aldo (n = 6) | KO‐Aldo (n = 6) |
|---|---|---|---|---|
| Pressure volume measurements | ||||
| HR (bpm) | 479.91 ± 16.79 | 487.18 ± 22.53 | 468 ± 19.17 | 451.15 ± 11.3 |
| LVESP (mmHg) | 114.38 ± 2.28 | 113.18 ± 2.09 | 125.08 ± 1.56* | 127.1 ± 2.32* |
| LVEDP (mmHg) | 6.16 ± 0.48 | 6.12 ± 0.69 | 7.91 ± 0.4* | 10.4 ± 0.56*,** |
| LVESV (uL) | 28.13 ± 0.62 | 27.82 ± 0.72 | 25.26 ± 0.83* | 25.22 ± 0.76* |
| LVEDV (uL) | 45.02 ± 0.74 | 45.22 ± 1.16 | 40.8 ± 1.04* | 40.45 ± 0.66* |
| SV (uL) | 20.29 ± 0.78 | 19.74 ± 0.54 | 18.32 ± 0.72* | 17.57 ± 0.84*,** |
| CO (mL/min) | 10 378 ± 255.71 | 9964.25 ± 306.88 | 8277.63 ± 286.63* | 7349.63 ± 300.32*,** |
| Ea (mmHg/uL) | 5.82 ± 0.24 | 5.93 ± 0.27 | 7.06 ± 0.27* | 8.05 ± 0.18*,** |
| Systolic function | ||||
| EF (%) | 43.15 ± 0.98 | 42.74 ± 1.59 | 43.8 ± 1.32 | 40.98 ± 1.38 |
| SW (mmHg*uL) | 1881 ± 96.38 | 1737.88 ± 76.67 | 1766.5 ± 75.19 | 1666.13 ± 52.61 |
| dp/dt max (mmHg/s) | 14 182.75 ± 678.67 | 14 441.25 ± 703.76 | 13 833.75 ± 702.75 | 12 286.25 ± 356.47* |
| Diastolic function | ||||
| TAU (ms) | 6 ± 0.34 | 6.27 ± 0.33 | 8.59 ± 0.22* | 10.51 ± 0.49*,** |
| dp/dt min (mmHg/s) | −10625.75 ± 305.95 | −11497.75 ± 697.78 | −9057.25 ± 200.11* | −7546 ± 321.78*,** |
CO, cardiac output; dp/dt max, maximum rate of increase in left ventricular pressure; dp/dt min, maximum rate of decrease in left ventricular pressure; Ea, arterial elastance (measure of ventricular afterload); EF, ejection fraction; HR, heart rate; LVEDP, left ventricular end‐diastolic pressure; LVEDV, left ventricular end‐diastolic volume; LVESP, left ventricular end‐systolic pressure; LVESV, left ventricular end‐systolic volume; SV, stroke volume; SW, stroke work; TAU, left ventricular isovolumetric relaxation constant (relaxation time constant calculated by the Weiss method).
Data express as Mean ± SEM.
*
P < 0.05 vs. WT‐Sal group.
**
P < 0.05 vs. WT‐Aldo group.