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. 2020 Apr 9;11:309. doi: 10.3389/fphys.2020.00309

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Copyright © 2020 Rocha-Santos, Braga, Ceroni and Michelini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Photomicrographs depicting changes in DBH + fibers (green, (A)) and OT+ neurons (red, (B)) within the posterior paraventricular nucleus (PVNpost) in rats treated with Dopamine β-hydroxilase-saporin (DBHx) or Saline (SHAM) and submitted to training (T) or sedentary (S) protocol. 3rd ventricle. (C) Three-dimensional rendered images comparing the density of DBH + overlapping boutons (arrows) and those that are close, but not overlapping (green) with oxytocin positive neurons (red) taken from PVNpost of SHAM-T and DBHx-T rats. Graphs show the quantification of the integrated density of DBH + projections (D, F) and OT+ neurons (E, G) within PVNpost (D, E) and PVNvm (F, G) in the 4 experimental groups. Values are the means of 2–4 slices/rat, four rats in each subgroup. Comparison made by Factorial two-way ANOVA. PVNpost – DBH density: group F(1,12) = 367.61, P < 0.001, condition F(1,12) = 52.05, P < 0.001, interaction F(1,12) = 18.86, P < 0.001; OT density: group F(1,12) = 322.51, P < 0.001; condition: F(1,12) = 7.68, P = 0.017, interaction: F(1,12) = 17.70, P = 0.001; PVNvm – DBH density: group F(1,12) = 257.92, P < 0.001, condition F(1,12) = 57.90, P < 0.001, interaction F(1,12) = 17.44, P = 0.001; OT density: group F(1,12) = 75.41, P < 0.001, condition F(1,12) = 0.76, P = 0.400, interaction F(1,12) = 8.49, P = 0.013. Significances (P < 0.05) are ° vs. Sedentary and * vs. respective SHAM group.