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. 2020 Mar 26;43(6):1964–1974. doi: 10.3892/or.2020.7565

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Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — USP19 inhibits the tumorigenesis of clear cell renal cell carcinoma cells in vivo. (A) Photographs of mouse xenografts generated by subcutaneous injection of Caki-1 cells; n=5/group. (B) Tumor volumes were evaluated after injection every 5 days for 60 days. (C) Weights of the xenografts were measured 60 days after injection. (D) Body weights of the mice were measured 60 days after injection. (E) Protein levels of USP19, p-ERK and total ERK in tumor tissue were analyzed via western blotting. Data are presented as the mean ± SD. *P<0.05, **P<0.01 vs. shctrl. USP, ubiquitin specific peptidase; p, phosphorylated; sh, short hairpin RNA; n.s., not significant.