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. 2020 Mar 26;43(6):1986–1994. doi: 10.3892/or.2020.7566

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Copyright: © Wei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Costunolide regulates metastasis- and proliferation-associated mRNA expression levels of H1299 lung cancer cells in vitro. H1299 cells were treated with different concentrations of costunolide for 6 and 12 h. (A) The mRNA expression levels of E-cadherin were upregulated in a dose-dependent manner. The mRNA expression levels of (B) N-cadherin, (C) integrin α2, (D) integrin β1, (E) MMP2 and (F) B-Raf were downregulated in a dose-dependent manner. Data are presented as the mean ± standard deviation (n=3). Differences between concentrations were tested using one-way ANOVA and Tukey's post hoc tests. *P<0.05, **P<0.01; NS, not significant. MMP2, matrix metalloproteinase-2; con, control.