Table II.
Clinicopathological characteristics according to primary tumor sidedness in RNF43 mutant colorectal cancer.
| Primary tumor sidedness | |||
|---|---|---|---|
| Variables | Right-sided N (%) | Left-sided N (%) | P-value |
| Age (years) | |||
| <65 | 1 (4) | 5 (18) | 0.182 |
| ≥65 | 11 (40) | 10 (37) | |
| Sex | |||
| Male | 3 (11) | 6 (22) | 0.683 |
| Female | 9 (33) | 9 (33) | |
| Tumor size (mm) | |||
| <50 | 5 (18) | 8 (29) | 0.704 |
| ≥50 | 7 (26) | 7 (26) | |
| pT category | |||
| T1, 2 | 1 (4) | 3 (11) | 0.605 |
| T3, 4 | 11 (40) | 12 (44) | |
| Histopathological grading | |||
| G1, 2 | 5 (18) | 14 (52) | 0.008 |
| G3 | 7 (26) | 1 (4) | |
| Lymphatic invasion | |||
| Absence | 3 (11) | 11 (40) | 0.021 |
| Presence | 9 (33) | 4 (15) | |
| Venous invasion | |||
| Absence | 4 (15) | 9 (33) | 0.252 |
| Presence | 8 (30) | 6 (22) | |
| pN category | |||
| N0 | 3 (11) | 7 (26) | 0.424 |
| N1, 2 | 9 (33) | 8 (30) | |
| cM category | |||
| M0 | 8 (30) | 10 (37) | 0.999 |
| M1 | 4 (15) | 5 (18) | |
| APC | |||
| Wild-type | 8 (30) | 1 (4) | 0.003 |
| Mutant | 4 (15) | 14 (52) | |
| KRAS | |||
| Wild-type | 11 (40) | 10 (37) | 0.182 |
| Mutant | 1 (4) | 5 (18) | |
| BRAF V600E | |||
| Wild-type | 2 (7) | 15 (55) | <0.001 |
| Mutant | 10 (37) | 0 (0) | |
| MSI | |||
| MSI-H | 7 (26) | 1 (4) | 0.008 |
| MSS | 5 (18) | 14 (52) | |
| Variants of RNF43 | |||
| Nonsense or frameshift | 11 (40) | 1 (4) | <0.001 |
| Missense | 1 (4) | 14 (52) | |
Fisher's exact test. MSI, microsatellite instability; MSI-H, microsatellite instability-high. Bold indicates P<0.05.