Table 2. Burst size needed for detection of mode change, for a wide choice of granule sizes.

K_β – Number of SNAREs for homotypic fusion at basal state; K_γ – Number of SNAREs for heterotypic fusion at basal state; μ/λ - effective kinetics factor; KLD_c - Kullback-Leibler Divergence of secreted granule content; MGS – Mean quantal granule size; MGD - Mean number of evokedly secreted granules until detection; STDGD – standard deviation of number of granules until detection; Burst – MGD+2*STDGD

Kβ	Kγ	μ/λ	MGS evoked	MGS basal	KLDC(e,b)	KLDC(b,e)	MGD (R=10)	STDGD (R=10)	Burst (R=10)	MGD (R=100)	STDGD (R=100)	Burst (R=100)
20	20	2	12.44	1.50	10.36	17.42	1.25	0.38	2.00	1.16	0.36	1.88
20	19	2	6.42	1.43	7.14	11.59	1.69	0.54	2.77	1.50	0.51	2.42
20	18	2	4.61	1.39	5.51	8.63	2.06	0.70	3.45	1.77	0.64	3.05
11	12	2	35.09	1.67	8.13	13.8	1.52	0.55	2.63	1.38	0.53	2.43
11	11	2	6.98	1.50	4.67	5.90	2.31	0.81	3.93	1.95	0.74	3.43
11	10	2	4.03	1.43	2.90	3.54	3.21	1.24	5.71	2.47	1.09	4.65
11	10	4	3.20	1.23	2.84	2.91	3.25	1.29	5.83	2.49	1.13	4.75
8	8	4	3.52	1.25	2.52	2.18	3.49	1.53	6.54	2.62	1.32	5.26
7	7	4	3.10	1.25	1.92	1.56	4.10	2.00	8.10	2.90	1.68	6.27
7	6	4	2.23	1.23	1.03	0.84	5.56	3.30	12.16	3.46	2.61	8.67
6	6	4	2.68	2.46	1.34	1.03	4.94	2.78	10.51	3.24	2.25	7.75
5	6	4	4.63	1.29	2.27	1.54	3.71	1.92	7.56	2.73	1.65	6.03
5	5	4	2.28	1.25	0.82	0.61	6.07	4.14	14.35	3.62	3.19	10.01
5	4	4	1.73	1.23	0.33	0.26	7.76	7.38	22.51	4.07	5.35	14.76
4	5	4	3.44	1.29	1.33	0.88	4.96	3.07	11.07	3.25	2.48	8.21
4	4	4	1.92	1.25	0.41	0.31	7.41	6.59	20.60	3.98	4.83	13.65
4	3	4	1.52	1.23	0.13	0.11	8.77	12.62	34.01	4.29	8.82	21.93
4	3	2	1.91	1.43	0.19	0.17	8.46	9.90	28.25	4.22	7.00	18.22