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. 2020 Apr 6;43(6):1785–1796. doi: 10.3892/or.2020.7578

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Copyright: © Joo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Hippo signaling pathway. Upon activation of Hippo signaling, YAP/TAZ are phosphorylated and sequestered in the cytoplasm, whereas TEAD and VGLL bind in the nucleus. When Hippo signaling is deactivated, YAP/TAZ are dephosphorylated and translocate to the nucleus to bind TEAD, activating the downstream transcription of target genes. TEAD, transcriptional enhancer associated domain; VGLL, vestigial like family; HCC, hepatocellular carcinoma; TEAD2, transcriptional enhancer associated domain 2; VGLL4, vestigial like family member 4; YAP, yes-associated protein.