Table II.
Genes regulating the Hippo pathway hepatocellular carcinoma. The gene alteration contains gene amplification, deep deletion, missense mutation (unknown significance), mRNA upregulation and truncating mutation (unknown significance) of each analysed gene on HCC tissues.
| Symbol | Gene name | Chromosome location | Gene alteration (%) |
|---|---|---|---|
| YAP1 | Yes-Associated Protein 1 | 11q22.1 | 7 |
| TAZ | Tafazzin | Xq28 | 9 |
| TEAD1 | TEA Domain Transcription Factor 1 | 11p15.3 | 4 |
| TEAD2 | TEA Domain Transcription Factor 2 | 19q13.33 | 6 |
| TEAD3 | TEA Domain Transcription Factor 3 | 6p21.31 | 13 |
| TEAD4 | TEA Domain Transcription Factor 4 | 12p13.33 | 8 |
| VGLL1 | Vestigial Like Family Member 1 | Xq26.3 | 3 |
| VGLL2 | Vestigial Like Family Member 2 | 6q22.1 | 3 |
| VGLL3 | Vestigial Like Family Member 3 | 3p12.1 | 4 |
| VGLL4 | Vestigial Like Family Member 4 | 3p25.2 | 6 |