Table IV.

Univariate and multivariate Cox regression analysis of prognostic clinical factors and clinical independence.

A, TCGA training datasets
	Univariate analysis			Multivariate analysis
Variable	HR	95% CI	P-value	HR	95% CI	P-value
8-gene risk score, High vs. low	3.233	2.163–4.833	<0.001a	2.56	1.8227–3.592	<0.001a
Age, >60 vs. ≤60 years	1.016	1.002–1.031	0.020a	1.014	0.9994–1.028	0.986
Grade, G3/G4 vs. G1/G2	1.201	0.757–1.904	0.436	1.112	0.7914–1.563	0.539
Stage, III vs. I/II	1.991	0.812–4.877	0.131	1.216	0.7877–1.877	0.377
Stage, IV vs. I/II	1.402	0.865–2.272	0.170
B, TCGA test datasets
	Univariate analysis			Multivariate analysis
Variable	HR	95% CI	P-value	HR	95% CI	P-value
8-gene risk score, High vs. low	1.958	1.103–3.473	0.021a	1.682	0.729–3.882	0.022a
Age, >60 vs. ≤60 years	1.024	0.996–1.052	0.083	1.026	0.997–1.056	0.075
Grade, G3/G4 vs. G1/G2	1.118	0.477–2.618	0.796	1.875	0.880–3.997	0.103
Stage, III vs. I/II	1.615	0.222–11.760	0.635	0.956	0.399–2.294	0.921
Stage, IV vs. I/II	1.379	0.479–3.972	0.551
C, GSE26193
	Univariate analysis			Multivariate analysis
Variable	HR	95% CI	P-value	HR	95% CI	P-value
8-gene risk score, High vs. low	2.341	1.374–3.988	0.002a	1.604	0.494–50.041	0.017a
Grade, G3/G4 vs. G1/G2	1.062	0.661–1.709	0.801	2.203	1.628–2.982	<0.001a
Stage, III vs. I/II	3.799	1.959–7.366	<0.001a	0.729	0.483–1.099	0.132
Stage, IV vs. I/II	2.442	1.582–3.768	<0.001a

^aP<0.05. TCGA, The Cancer Genome Atlas; HR, hazard ratio; CI, confidence interval.