Table 2.
Calculated ADME parameters of the designed compounds.
| Comp | MW | iLOGP | HBD | HBA | TPSA | RB | nAH | MR | PAINS #alert | Brenk #alert |
|---|---|---|---|---|---|---|---|---|---|---|
| 9a | 480.21 | 2.35 | 1 | 9 | 71.62 | 7 | 12 | 94.45 | 0 | 0 |
| 9b | 461.76 | 2.28 | 2 | 10 | 91.85 | 7 | 12 | 91.46 | 0 | 0 |
| 9c | 477.83 | 2.25 | 1 | 9 | 110.42 | 7 | 12 | 96.69 | 0 | 1 |
| 9d | 480.21 | 2.11 | 1 | 9 | 71.62 | 7 | 12 | 94.45 | 0 | 0 |
| 9e | 460.78 | 1.86 | 2 | 9 | 97.64 | 7 | 12 | 93.85 | 0 | 1 |
| 9f | 480.21 | 2.35 | 1 | 9 | 71.62 | 7 | 12 | 94.45 | 0 | 0 |
| 9g | 512.27 | 1.94 | 1 | 9 | 110.42 | 7 | 12 | 101.7 | 0 | 1 |
| 9h | 493.83 | 2.22 | 2 | 10 | 130.65 | 7 | 12 | 98.72 | 0 | 1 |
| 9i | 479.75 | 1.8 | 2 | 11 | 91.85 | 7 | 12 | 91.42 | 0 | 0 |
| 9j | 461.76 | 2.1 | 2 | 10 | 91.85 | 7 | 12 | 91.46 | 0 | 0 |
| 9k | 463.73 | 2.61 | 1 | 10 | 71.62 | 7 | 12 | 89.4 | 0 | 0 |
| 9l | 555.85 | 2.76 | 2 | 11 | 91.85 | 8 | 18 | 116.68 | 0 | 0 |