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. 2019 Dec 27;9(4):679–688. doi: 10.1016/j.jcmgh.2019.12.008

Figure 5.

Figure 5

M2 macrophages were increased in Casp1–/–BDL mouse livers. (A) Cell type–specific gene mRNA expression. Elane for neutrophils, Cd3e for T cells, F4/80 for macrophages. (B) mRNA expression of macrophages M1 and M2 phenotype gene markers (WT sham, n = 7; WT BDL, n = 7; Casp1–/– sham, n = 5; Casp1–/– BDL, n = 6). Data presented as mean ± SD. (C) Representative images of immunohistochemistry staining of F4/80 (top, 100×) and immunofluorescent labeling of CD206 (bottom, 200×) of liver sections from BDL WT and Casp1–/– mice and their quantitative assessments of randomly selected microscopic fields. For F4/80, 6 images/section were acquired from randomly selected 4 animals in each group. For CD206, 5 images/section were acquired from randomly selected 3 animals in each group. The typical CD206/positive cells were indicated by the white arrows. n.s., not significant.