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A subpopulation of Diversity Outbred mice is highly susceptible to aerogenic M. tuberculosis challenge. Groups of 10 male B6 and 35 male DO mice were infected by aerosol with ∼150 CFU of M. tuberculosis. Bacterial uptake was determined by euthanizing one group of five B6 mice 4 h after infection and determining total lung M. tuberculosis burdens. Survival curves determined for B6 and DO mice were significantly different (Wilcoxon test, P = 0.0007).
