Table 8.
Summary of relevanta hematology results, 90-day study.
| Group‡ mg/kg bw/day | EOS (%) | MCV (fL) | PLT (×109/L) | RET (%) | |
|---|---|---|---|---|---|
| Males | |||||
| Control | Mean | 2.07 | 54.28 | 679.0 | 1.80 |
| SD | 0.56 | 2.32 | 150.0 | 0.20 | |
| 500 | Mean | 2.48 | 52.44 | 739.1 | 1.60 |
| SD | 3.12 | 1.50 | 154.1 | 0.15 | |
| SS | ∗ | ||||
| 1000 | Mean | 1.79 | 53.98 | 741.3 | 1.54 |
| SD | 1.02 | 1.51 | 90.4 | 0.24 | |
| SS | ∗ | ||||
| 2000 | Mean | 1.21 | 53.02 | 818.4 | 1.55 |
| SD | 0.28 | 1.72 | 111.4 | 0.34 | |
| SS | ∗∗ | ∗ | |||
| Test for significance | U | DN | NS | DN | |
| Historical control range | 0.3–9.0 | 45.4–53.7 | 595–957 | 2.05–4.65 | |
|
| |||||
| Females | |||||
| Control | Mean | 2.23 | 55.63 | 707.2 | 2.18 |
| SD | 0.84 | 1.56 | 151.8 | 0.34 | |
| 500 | Mean | 1.64 | 55.32 | 786.3 | 1.93 |
| SD | 0.81 | 1.36 | 136.1 | 0.36 | |
| 1000 | Mean | 1.49 | 53.97 | 892.6 | 1.80 |
| SD | 0.37 | 1.43 | 100.1 | 0.40 | |
| SS | ∗∗ | ||||
| 2000 | Mean | 1.52 | 54.69 | 849.4 | 1.90 |
| SD | 0.81 | 1.97 | 109.3 | 0.34 | |
| SS | ∗ | ||||
| Test for significance | NS | NS | DN | NS | |
| Historical control range | 0.4–2.1 | 47.0–60.1 | 549–1103 | 2.77–5.63 | |
Abbreviations: EOS: eosinophils; DN: Duncan's multiple range test; MCV: mean corpuscular volume; NS: nonsignificant; PLT: platelets; RET: reticulocytes; SD: standard deviation; SS: statistical significance; U: Mann–Whitney U-test versus control. a Only statistically significant findings are shown. ‡n = 10 for all groups. ∗p < 0.05, ∗∗p < 0.01.