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Constraints of factors and responses for the optimization of release rate and DC of theophylline loaded CLS.
| Constraints | ||||
|---|---|---|---|---|
| Factor constraints | ||||
| Factor | Low | High | ||
| Conc. ECH (%) | 3 | 16 | ||
| Length of cross-linking time (h) | 1 | 10 | ||
| Response constraints | ||||
| Response | Goal | Lower limit | Upper limit | Importance |
| Release rate (h1/2) | Target = 28 | 26 | 30 | +++++ |
| Degree of cross-linking (%) | Maximize | 60 | 90 | ++++ |
