Table 7.
Rate constants and correlation coefficients of the drug release kinetic models for all the thirteen microsphere formulations.
| Formulations | Release kinetic models | |||||||
|---|---|---|---|---|---|---|---|---|
| Zero-order | First-order | Higuchi square root | Hixson-Crowell | |||||
| Slope | R 2 | Slope | R 2 | Slope | R 2 | Slope | R 2 | |
| F-1 | 9.859 | 0.990 | -0.069 | 0.771 | 29.71 | 0.994 | -0.191 | 0.815 |
| F-2a | 6.652 | 0.887 | -0.094 | 0.887 | 29.80 | 0.979 | -0.181 | 0.905 |
| F-3 | 6.400 | 0.916 | -0.059 | 0.707 | 27.60 | 0.994 | -0.188 | 0.830 |
| F-4 | 4.628 | 0.854 | -0.034 | 0.728 | 22.00 | 0.986 | -0.158 | 0.901 |
| F-5b | — | — | — | — | — | — | — | — |
| F-6c | 6.159 | 0.815 | -0.057 | 0.606 | 26.01 | 0.968 | -0.168 | 0.842 |
| F-7d | 6.307 | 0.945 | -0.067 | 0.783 | 31.71 | 0.995 | -0.147 | 0.829 |
| F-8e | 4.207 | 0.987 | -0.089 | 0.855 | 24.03 | 0.975 | -0.179 | 0.913 |
| F-9 | 6.931 | 0.844 | -0.083 | 0.586 | 26.50 | 0.978 | -0.126 | 0.928 |
| F-10 | 5.069 | 0.782 | -0.061 | 0.564 | 28.30 | 0.952 | -0.184 | 0.860 |
| F-11 | 4.111 | 0.897 | -0.058 | 0.714 | 27.23 | 0.994 | -0.118 | 0.931 |
| F-12 | 5.965 | 0.881 | -0.064 | 0.653 | 27.40 | 0.990 | -0.152 | 0.893 |
| F-13 | 6.405 | 0.985 | -0.130 | 0.905 | 26.92 | 0.974 | -0.128 | 0.851 |
“-”: denotes for not analyzed.