Table 9.
Summaries of the experimental values of the microsphere formulations in terms of both actual and coded terms of the factor levels and response parameters.
| Formulations | Point type | Factors | Responses | ||
|---|---|---|---|---|---|
| (ECH) (%, w/w) | Cross-linking time (h) | Degree of cross-linking (%) | Release rate (h1/2) | ||
| F-1 | Factorial | 3.00 (-1) | 1.00 (-1) | 33.5 | 29.7 |
| F-2a | Factorial | 16.00 (+1) | 1.00 (-1) | 55.3 | 29.8 |
| F-3 | Factorial | 3.00 (-1) | 10.00 (+1) | 44.6 | 27.6 |
| F-4 | Factorial | 16.00 (+1) | 10.00 (+1) | 97.3 | 22.0 |
| F-5b | Axial | 0.31 (-α) | 5.50 (0) | 30.7 | 30.3 |
| F-6c | Axial | 18.69 (+α) | 5.50 (0) | 89.4 | 26.0 |
| F-7d | Axial | 9.50 (0) | 0.86 (-α) | 39.5 | 31.7 |
| F-8e | Axial | 9.50 (0) | 11.86 (+α) | 84.6 | 24.0 |
| F-9 | Center point | 9.50 (0) | 5.50 (0) | 76.4 | 26.5 |
| F-10 | Center point | 9.50 (0) | 5.50 (0) | 73.5 | 28.3 |
| F-11 | Center point | 9.50 (0) | 5.50 (0) | 74.6 | 27.2 |
| F-12 | Center point | 9.50 (0) | 5.50 (0) | 69.3 | 27.4 |
| F-13 | Center point | 9.50 (0) | 5.50 (0) | 82.7 | 26.9 |