Figure 2:

A potential example framework showing how relationships between mechanistic data from different sources can be organized. Mechanistic data relevant to neurodevelopment are mapped using the adverse outcome pathway construct. In this example, the adverse effects are a change in layer thickness, and the original molecular initiating event (MIE) is an effect on cyclin dependent kinase (CDK). There are many potential MIEs, pathways, events, and adverse effects that could populate this framework. (, ROS=reactive oxygen species, AChE= acetylcholinesterase, VGCC = voltage gated calcium channel,, Learning & Memory (L/M), Neurotransmitter (NT), electroencephalogram (EEG), long term potentiation (LTP,), GO =gene ontology KEEG =Kyoto Encyclopedia of Genes and Genomes).