Table 2.
Relevant significantly enriched biological process gene ontology terms for modules with expression patterns significantly affected by SNI (vs. Naïve) and reversed significantly by SCS.
| Module | Biological process gene ontology terms | SCS therapy |
|---|---|---|
| 1 | Regulation of transport, signaling, trans-synaptic signaling, cell–cell signaling, G-protein-coupled receptor signaling pathway, cellular calcium ion homeostasis | N.A. |
| 2 | Response to stress, regulation of immune system process, regulation of response to stimulus, signal transduction, regulation of transport | DTMP |
| 3 | Translation, peptide biosynthetic process, RNA metabolic process | DTMP |
| 6 | Response to oxygen levels, cellular developmental process, tissue development | N.A. |
| 7 | Cell–cell signaling, synaptic signaling, trans-synaptic signaling, regulation of protein phosphorylation, regulation of MAPK cascade, regulation of nervous system development, regulation of ion transport, regulation of nervous system development | DTMP |
| 9 | Regulation of cell-cycle process, DNA repair, cellular response to stress | DTMP, LR |
| 10 | Cellular response to stress, regulation of mRNA processing, primary metabolic process | HR |
| 11 | Signal transduction | N.A. |
| 12 | Signal transduction by trans-phosphorylation, response to chemokine, regulation of metallopeptidase activity | DTMP |
| 13 | Neurotransmitter receptor transport, regulation of postsynaptic membrane neurotransmitter receptor levels, protein transport within plasma membrane | DTMP |
| 16 | Sphingosine-1-phosphate receptor signaling pathway | DTMP |
| 17 | Regulation of neurogenesis, regulation of BMP signaling pathway, regulation of signal transduction | N.A. |
| 21 | N.A. | DTMP, LR |
| 22 | Axon ensheathment, myelin assembly, chemical homeostasis | N.A. |
| 23 | Cellular metabolic process, adenosine receptor signaling pathway, aerobic respiration | HR |
| 25 | Immune system process, regulation of cell-cell adhesion, cytokine-mediated signaling pathway, regulation of response to stress | HR |
| 28 | Ion transport, G-protein-coupled receptor signaling pathway, transmembrane transport | N.A. |
| 29 | rRNA metabolic process, glycosyl compound biosynthetic process | HR |
| 30 | Regulation of reactive oxygen species metabolic process, regulation of cytokine production, regulation of immune system process, inflammatory response | DTMP |
| 36 | Regulation of myelination, regulation of gliogenesis | DTMP |
| 37 | Regulation of amyloid precursor protein biosynthetic process, neuropeptide signaling pathway | N.A. |
| 38 | N.A. | DTMP |
| 39 | Lipid homeostasis | HR |
N.A.: did not render any enrichment; MAPK = Mitogen-Activated Protein Kinase; BMP = Bone Morphogenetic Protein.