Fig. 2.

MAGL inhibitor MJN110 dosed chronically reverses established flinching induced by CIBP. (A) Flinching was dose dependently and significantly reduced by systemic injection of MJN110 (once daily, 7 days) after femoral inoculation with 66.1 breast adenocarcinoma cells. (B) Guarding behaviors were not significantly reduced with chronic dosing of MJN110. Daily drug injections began immediately following CIBP baseline measurements. *P < 0.05; **P < 0.01, n = 8–12 animals per group (Two-way RM ANOVA, Bonferroni test). BL, baseline; D, day.