Fig. 4.

MJN110 had no effect on radiographic evidence of cancer-induced bone lesions. (A) Radiographs were taken of the ipsilateral femur at D0 prior to surgery and at D14 at the end of the study. Compared with vehicle control, there was no significant difference found between groups (F = 1.205, P = 0.4704). Images displayed are representative at D14 postsurgery. (B) Bones were evaluated using a five-point bone rating scale by three blinded individuals, and scores were averaged. The bone scoring scale was as follows: 0 = normal bone, 1 = 1–3 lesions with no fracture, 2 = 4+ lesions with no fracture, 3 = unicortical, full-thickness fracture, and 4 = bicortical, full-thickness fracture (two-way RM ANOVA, Bonferroni test). D, day; RM, repeated measures.