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The crosstalk of DNA methylation and DNA hydroxymethylation in the progress of the tumor. In many different kinds of cancers, IDH1, and IDH2 will mutate which can restrain the production of α-ketoglutarate and produce 2HG. Both of these two phenomena will lead to the inhibition of TET family and meanwhile, the low level of 5-hmC can promote the activity of DNMT1. These two pathways will finally result in the tumorigenesis.
